propofol attenuates toxic oxidative stress by ccl4 in liver mitochondria and blood in rat

Authors

akram ranjbar department of toxicology and pharmacology, school of pharmacy, hamadan university of medical sciences, hamadan, iran

mohammad sharifzadeh faculty of pharmacy, and pharmaceutical sciences research center, tehran university of medical sciences, tehran, iran

jamshid karimi department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran.

heidar tavilani tavilani department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran

abstract

anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet ccl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). group i (control), while group ii was given ccl4 (3 ml /kg/day, ip). animals of groups iii received only propofol (10 mg/kg/day, ip). group iv was given propofol+ ccl4. group v was administered vitamin e (alpha-tocopherol acetate 15 mg/kg/day, sc) .animals of group vii received alpha-tocopherol acetate + ccl4 once daily for two weeks. after treatment, blood and liver mitochondria were isolated. anti-oxidant enzymes activity such as glutathione peroxidase (gpx), superoxide dismutase (sod) and oxidative stress marker such as reduced glutathione (gsh) and lipid peroxidation (lpo) concentration were measured. oxidative stress induced with ccl4 in liver mitochondria was evident by a significant increase in enzymatic activities of gpx, sod, and lpo and decreased of gsh and vailability of mitochondria. propofol and vitamin e restored ccl4-induced changes in gsh, gpx, sod and lpo in blood and liver mitochondria. ccl4 decreased viability of mitochondria that was recovered by propofol and vitamin e. it is concluded that oxidative damage is the mechanism of toxicity of ccl4 in the mitochondria that can be recovered by propofol comparable to vitamin e.

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Journal title:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۱، صفحات ۲۵۳-۲۶۲

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